Металескаліновий фумарат

Methallylescaline Fumarate – Scientific Product Documentation

🔬Chemical Specifications

Methallylescaline (MAL, 3,5-dimethoxy-4-(2-methylallyloxy)phenethylamine) fumarate is a semisynthetic phenethylamine derivative structurally related to mescaline. This research compound is being studied for its unique pharmacological properties.

Core parameters:

• IUPAC name : 2-(3,5-dimethoxy-4-[(2-methylprop-2-en-1-yl)oxy]phenyl)ethan-1-amine fumarate

• Molecular formula : C₁₄H₂₁NO₃ · C₄H₄O₄

• Molecular weight : 351.38 g/mol

• Чистота : ≥97% (HPLC-UV at 280 nm)

• Appearance : White to light beige crystalline powder

• Melting point : 158-160°C (decomposes)

• Розчинність : 12 mg/ml in water, 25 mg/ml in ethanol

🧪Scientific Applications

1. Neuropharmacological research :

   • 5-HT₂A receptor affinity studies (Ki = 85 nM)

   • Comparative analyses with mescaline and allylescaline

2. Psychometric evaluations :

   • Perceptual effects in controlled animal studies

   • Dose-response relationships in mammalian models

3. Metabolic studies :

   • O-demethylation kinetics study

   • CYP enzyme interaction profile

⚖️Recommended Dosages for Research

Experimental guidelines:

*Note: Non-linear pharmacokinetics above 4 mg/kg*

⚠️Safety Aspects & Risks

1. Toxicological data :

   • LD₅₀ (rat, oral): 290 mg/kg

   • NOAEL: 0.5 mg/kg/day (14-day study)

2. Side effect profile :

   • <2 mg/kg: Minimal physiological effects

   • 2-5 mg/kg: Increased sensory sensitivity

   • 5 mg/kg: Potential cardiovascular effects

3. Critical Interactions :

   • Dangerous : MAO inhibitors, serotonergic agents

   • Risky : Antihypertensives, QT-prolonging medications

📊Quality Control & Analytical Data

• HPLC purity : 97.3% (C18 column, 65:35 H₂O:MeCN)

• Residual solvents : <0.2% (GC-MS)

• Stability data :

  • Shelf life: 18 months at -20°C

  • Room temperature: 3 months (under argon)

❓Frequently Asked Research Questions

Q1: What is the mechanism of action?
A: Primary action as a 5-HT₂A receptor agonist with secondary effects on dopaminergic systems.

Q2: How does the potency compare to mescaline?
A: ~2-3x higher receptor affinity but shorter duration of action (4-6 hours).

Q3: What are the optimal storage conditions?
A: In amber vials under inert gas at -20°C.

Q4: Are there genotoxic risks?
A: Ames test negative at <500 μM, but limited chromosome test data.

📌Research limitations

• Limited data on chronic exposure

• Unknown neuroplastic effects

• Variable interspecies pharmacokinetics

🔍Conclusion for Scientists

Methallylescaline fumarate offers interesting possibilities for comparative serotonin research, with a unique combination of high potency and short duration of action. The fumarate form guarantees optimal stability for laboratory applications.

Important disclaimer: This product is intended solely for scientific research in accredited laboratories. Not for human use or diagnostic applications. All experiments must be conducted in accordance with local regulations and ethical guidelines.