{"id":23497,"date":"2025-04-13T17:39:53","date_gmt":"2025-04-13T17:39:53","guid":{"rendered":"https:\/\/purematrixchem.com\/?post_type=product&p=23497"},"modified":"2026-06-28T11:46:46","modified_gmt":"2026-06-28T10:46:46","slug":"5-meo-dmt-freebase","status":"publish","type":"product","link":"https:\/\/purematrixchem.com\/tr\/magaza\/5-meo-dmt-satin-al\/5-meo-dmt-freebase\/","title":{"rendered":"5-MeO-DMT serbest baz"},"content":{"rendered":"

5-MeO-DMT Serbest Baz \u2013 Bilimsel \u00dcr\u00fcn Belgeleri<\/span><\/span><\/strong><\/h3>\n

Genel A\u00e7\u0131klama<\/span><\/span><\/strong><\/h4>\n

5-MeO-DMT (5-Metoksi-N,N-dimetiltriptamin) serbest baz, \u00e7e\u015fitli bitkilerde ve hayvan salg\u0131lar\u0131nda bulunan, g\u00fc\u00e7l\u00fc bir psikoaktif profile sahip, do\u011fada olu\u015fan bir triptamindir. Serbest baz formunda, belirli ara\u015ft\u0131rma y\u00f6ntemleri i\u00e7in \u00fcst\u00fcn u\u00e7uculuk \u00f6zelli\u011fi sunar; bu da onu farmakolojik ve sinirbilim \u00e7al\u0131\u015fmalar\u0131 i\u00e7in de\u011ferli k\u0131lar.<\/span><\/span><\/p>\n

\n

Teknik \u00d6zellikler<\/span><\/span><\/strong><\/h3>\n
\n\n\n\n\n\n\n\n\n\n\n\n
Parametre<\/span><\/span><\/strong><\/th>\n\u015eartname<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
Kimyasal Form\u00fcl<\/span><\/span><\/td>\nC\u2081\u2083H\u2081\u2088N\u2082O<\/span><\/span><\/td>\n<\/tr>\n
Molek\u00fcler A\u011f\u0131rl\u0131k<\/span><\/span><\/td>\n218,29 g\/mol<\/span><\/span><\/td>\n<\/tr>\n
Safl\u0131k<\/span><\/span><\/td>\n\u226598% (HPLC-UV ile analiz edildi)<\/span><\/span><\/td>\n<\/tr>\n
Form<\/span><\/span><\/td>\nKristalimsi\/beyaz toz<\/span><\/span><\/td>\n<\/tr>\n
\u00c7\u00f6z\u00fcn\u00fcrl\u00fck<\/span><\/span><\/td>\nOrganik \u00e7\u00f6z\u00fcc\u00fclerde (etanol, metanol, DMSO) \u00e7\u00f6z\u00fcn\u00fcr; suda s\u0131n\u0131rl\u0131 \u00e7\u00f6z\u00fcn\u00fcrl\u00fck g\u00f6sterir<\/span><\/span><\/td>\n<\/tr>\n
Erime noktas\u0131<\/span><\/span><\/td>\n60-65 \u00b0C (serbest baz)<\/span><\/span><\/td>\n<\/tr>\n
\u0130stikrar<\/span><\/span><\/td>\nI\u015f\u0131\u011fa ve oksijene duyarl\u0131; inert gaz alt\u0131nda saklay\u0131n\u0131z<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n

Bilimsel Uygulamalar<\/span><\/span><\/strong><\/h3>\n

1. N\u00f6rofarmakolojik Ara\u015ft\u0131rmalar<\/span><\/span><\/strong><\/h4>\n
    \n
  • \n

    Serotonerjik Etki:<\/span><\/span><\/strong> \u00a0G\u00fc\u00e7l\u00fc bir 5-HT\u2081\u2090\/\u2082\u2090 agonisti; bilin\u00e7 mod\u00fclasyonu \u00fczerine yap\u0131lan \u00e7al\u0131\u015fmalarda \u00f6nem arz eder.<\/span><\/span><\/p>\n<\/li>\n

  • \n

    EEG\/fMRI \u00e7al\u0131\u015fmalar\u0131:<\/span><\/span><\/strong> \u00a0Beyin dalga kal\u0131plar\u0131 (\u00f6rne\u011fin gama sal\u0131n\u0131mlar\u0131) \u00fczerindeki akut etkilerin ara\u015ft\u0131r\u0131lmas\u0131.<\/span><\/span><\/p>\n<\/li>\n

  • \n

    N\u00f6roplastisite:<\/span><\/span><\/strong> \u00a0BDNF\u2019yi art\u0131r\u0131c\u0131 olas\u0131 etkiler (hayvan modellerinde).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    2. Metabolik ve Toksikolojik \u00c7al\u0131\u015fmalar<\/span><\/span><\/strong><\/h4>\n
      \n
    • \n

      MAO\u2019ya ba\u011fl\u0131 metabolizma:<\/span><\/span><\/strong> \u00a0CYP2D6 ve MAO-A bozunma yollar\u0131n\u0131n incelenmesi.<\/span><\/span><\/p>\n<\/li>\n

    • \n

      Doz ba\u011f\u0131ml\u0131 toksisite:<\/span><\/span><\/strong> \u00a0H\u00fccre k\u00fclt\u00fcrlerinde g\u00fcvenlik marjlar\u0131n\u0131n belirlenmesi.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

      3. Kar\u015f\u0131la\u015ft\u0131rmal\u0131 Farmakoloji<\/span><\/span><\/strong><\/h4>\n
        \n
      • \n

        DMT ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda:<\/span><\/span><\/strong> \u00a0Etki g\u00fcc\u00fc daha y\u00fcksek olmakla birlikte etki s\u00fcresi daha k\u0131sad\u0131r (inhalasyon yoluyla al\u0131nd\u0131\u011f\u0131nda 15-30 dakika).<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Psilosibin ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda:<\/span><\/span><\/strong> \u00a0Resept\u00f6r afinitesi ve \u00f6znel etkiler a\u00e7\u0131s\u0131ndan farkl\u0131l\u0131klar.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

        \n

        Deneysel K\u0131lavuzlar<\/span><\/span><\/strong><\/h3>\n

        \u00d6nerilen Konsantrasyonlar (In Vitro)<\/span><\/span><\/strong><\/h4>\n
        \n\n\n\n\n\n\n\n
        Uygulama<\/span><\/span><\/th>\nKonsantrasyon aral\u0131\u011f\u0131<\/span><\/span><\/th>\n\u00c7\u00f6z\u00fcc\u00fc<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n
        Resept\u00f6r ba\u011flanma testleri<\/span><\/span><\/td>\n1 nM \u2013 10 \u00b5M<\/span><\/span><\/td>\nPBS\/DMSO (\u22640,11 TP3T)<\/span><\/span><\/td>\n<\/tr>\n
        H\u00fccre k\u00fclt\u00fcr\u00fc deneyleri<\/span><\/span><\/td>\n0,1 \u2013 100 \u00b5M<\/span><\/span><\/td>\nDMEM\/FBS<\/span><\/span><\/td>\n<\/tr>\n
        Gaz kromatografisi<\/span><\/span><\/td>\n1 mg\/ml (metanol i\u00e7inde)<\/span><\/span><\/td>\nMetanol (HPLC s\u0131n\u0131f\u0131)<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

        G\u00fcvenlik protokolleri<\/span><\/span><\/strong><\/h4>\n
          \n
        • \n

          Ki\u015fisel Koruma:<\/span><\/span><\/strong> \u00a0Tozla \u00e7al\u0131\u015f\u0131rken laboratuvar \u00f6nl\u00fc\u011f\u00fc, nitril eldivenler, koruyucu g\u00f6zl\u00fck ve FFP2 maskesi kullan\u0131lmal\u0131d\u0131r.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Havaland\u0131rma:<\/span><\/span><\/strong> \u00a0Is\u0131tma veya buharla\u015ft\u0131rma i\u015flemleri s\u0131ras\u0131nda daima \u00e7eker ocak alt\u0131nda \u00e7al\u0131\u015f\u0131n.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Depolama:<\/span><\/span><\/strong> \u00a0Kehribar rengi \u015fi\u015felerde, argon ortam\u0131nda, -20 \u00b0C\u2019de (uzun s\u00fcreli saklama).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

          \n

          Stabilite ve Depolama<\/span><\/span><\/strong><\/h3>\n
            \n
          • \n

            Raf \u00f6mr\u00fc:<\/span><\/span><\/strong><\/p>\n

              \n
            • \n

              Oda s\u0131cakl\u0131\u011f\u0131nda: \u00c7\u00f6zeltide <24 saat.<\/span><\/span><\/p>\n<\/li>\n

            • \n

              4 \u00b0C: 3 g\u00fcn boyunca kararl\u0131d\u0131r (argon ortam\u0131nda).<\/span><\/span><\/p>\n<\/li>\n

            • \n

              -20 \u00b0C: >6 ay (safl\u0131kta de\u011fi\u015fiklik olmaz).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

            • \n

              Par\u00e7alanma \u00fcr\u00fcnleri:<\/span><\/span><\/strong><\/p>\n

                \n
              • \n

                \u0130ndol t\u00fcrevlerine oksidasyon (TLC\/HPLC ile kontrol edin).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                \n

                Analitik Sertifikasyon<\/span><\/span><\/strong><\/h3>\n

                Her parti \u015funlar\u0131 i\u00e7erir:<\/span><\/span><\/p>\n

                  \n
                1. \n

                  HPLC-UV kromatogram\u0131<\/span><\/span><\/strong> \u00a0(\u03bb=280 nm, C18 kolonu)<\/span><\/span><\/p>\n<\/li>\n

                2. \n

                  GC-MS ile do\u011frulama<\/span><\/span><\/strong> \u00a0(karakteristik par\u00e7ac\u0131klar: m\/z 174, 160)<\/span><\/span><\/p>\n<\/li>\n

                3. \n

                  Kalan \u00e7\u00f6z\u00fcc\u00fc analizi<\/span><\/span><\/strong> \u00a0(\u2264500 ppm)<\/span><\/span><\/p>\n<\/li>\n

                4. \n

                  Su i\u00e7eri\u011fi<\/span><\/span><\/strong> \u00a0(Karl Fischer, <1%)<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                  \n

                  Yasal Durum (Hollanda)<\/span><\/span><\/strong><\/h3>\n
                    \n
                  • \n

                    Afyon Kanunu:<\/span><\/span><\/strong> \u00a0A\u00e7\u0131k\u00e7a d\u00fczenlenmemi\u015ftir, ancak muhtemelen benzer mevzuat kapsam\u0131nda de\u011ferlendirilebilir.<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Yasalar:<\/span><\/span><\/strong> \u00a0Bilimsel kurumlar i\u00e7in lisans al\u0131nmas\u0131 zorunludur (Ek 2, Afyon Kanunu).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    \u0130hracat k\u0131s\u0131tlamalar\u0131:<\/span><\/span><\/strong> \u00a0CITES listesine al\u0131nmas\u0131 (a\u015fa\u011f\u0131dakiler gibi do\u011fal kaynaklar nedeniyle:\u00a0 <\/span><\/span>Incilius alvarius<\/span><\/span><\/em> ).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                    \n

                    S\u0131k\u00e7a Sorulan Sorular (SSS)<\/span><\/span><\/strong><\/h3>\n

                    S1: Serbest baz ile fumarik asit tuzu aras\u0131ndaki fark nedir?<\/span><\/span><\/strong>
                    \n C: Freebase daha u\u00e7ucudur (buharla\u015fma deneyleri i\u00e7in uygundur), oysa fumarik asit tuzu \u00e7\u00f6zeltilerde daha kararl\u0131d\u0131r.<\/span><\/span><\/p>\n

                    Soru 2: Toksikoloji taramalar\u0131nda 5-MeO-DFT nas\u0131l tespit edilir?<\/span><\/span><\/strong>
                    \n C: A\u015fa\u011f\u0131daki \u00f6zelliklerden tan\u0131nabilir:<\/span><\/span><\/p>\n

                      \n
                    • \n

                      LC-MS\/MS (\u00f6nc\u00fc iyon m\/z 219 \u2192 \u00fcr\u00fcn iyonu m\/z 174)<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      \u0130mm\u00fcnoassaylar: Baz\u0131 DMT testleriyle \u00e7apraz reaktivite (\u226430%).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      Soru 3: Bilinen herhangi bir farmakokinetik etkile\u015fim var m\u0131?<\/span><\/span><\/strong>
                      \n A:\u00a0 <\/span><\/span>Tehlikeli kombinasyonlar:<\/span><\/span><\/strong><\/p>\n

                        \n
                      • \n

                        MAO inhibit\u00f6rleri (serotonin sendromu riski).<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        SSRI\u2019lar (rekabet nedeniyle etkinlikte azalma).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                        S4: At\u0131klar nas\u0131l bertaraf edilir?<\/span><\/span><\/strong>
                        \n C: A\u015fa\u011f\u0131dakilerle etkisiz hale getirin:<\/span><\/span><\/p>\n

                          \n
                        1. \n

                          N\u00f6tralizasyon i\u00e7in seyreltilmi\u015f hidroklorik asit (0,1 M).<\/span><\/span><\/p>\n<\/li>\n

                        2. \n

                          Aktif karbonla emilim.<\/span><\/span><\/p>\n<\/li>\n

                        3. \n

                          Olarak imha edin\u00a0 <\/span><\/span>tehlikeli kimyasal at\u0131klar<\/span><\/span><\/em> \u00a0(BM numaras\u0131: 3249).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                          \n

                          Referanslar & \u0130leti\u015fim<\/span><\/span><\/strong><\/h3>\n

                          \u00d6nemli yay\u0131nlar:<\/span><\/span><\/strong><\/p>\n

                            \n
                          • \n

                            Sz\u00e1ra, S. (2007). \u201cDMT ve 5-MeO-DMT: Erken d\u00f6nem insan \u00e7al\u0131\u015fmalar\u0131\u201d.<\/span><\/span><\/p>\n<\/li>\n

                          • \n

                            Uthaug ve ark. (2021). \u201c5-MeO-DMT\u2019nin Psikofarmakolojisi\u201d.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                            \n

                            Bu \u00fcr\u00fcn, yaln\u0131zca me\u015fru bilimsel ara\u015ft\u0131rma ama\u00e7l\u0131d\u0131r. \u0130nsanlar veya hayvanlar \u00fczerinde kullan\u0131lmamal\u0131d\u0131r. Kullan\u0131c\u0131lar, t\u00fcm yerel d\u00fczenlemelere uymak zorundad\u0131r.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                            5-MeO-DMT freebase properties<\/span><\/span><\/span><\/span><\/h3>\n

                            Synonym:<\/span><\/span><\/span><\/span><\/strong> 5-methoxy-N,N-dimethyltryptamine <\/span><\/span><\/span><\/span>
                            \nCAS Number:<\/span><\/span><\/span><\/span><\/strong> 1019-45-0 <\/span><\/span><\/span><\/span>
                            \nFormula:<\/span><\/span><\/span><\/span><\/strong> 3-[2-(dimethylamino)ethyl]-5-methoxyindole <\/span><\/span><\/span><\/span>
                            \nMolar Mass:<\/span><\/span><\/span><\/span><\/strong> 218.3 g\/mol <\/span><\/span><\/span><\/span>
                            \nPurity:<\/span><\/span><\/span><\/span><\/strong> >97%<\/span><\/span><\/span><\/span><\/p>\n","protected":false},"featured_media":29431,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[82],"product_cat":[511,381],"product_tag":[1189],"class_list":["post-23497","product","type-product","status-publish","has-post-thumbnail","product_brand-research-chemical","product_cat-5-meo-dmt-kopen","product_cat-tryptamines","product_tag-5-meo-dmt-freebase-nl","first","instock","taxable","shipping-taxable","purchasable","product-type-variable"],"_links":{"self":[{"href":"https:\/\/purematrixchem.com\/tr\/wp-json\/wp\/v2\/product\/23497","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/purematrixchem.com\/tr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/purematrixchem.com\/tr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/purematrixchem.com\/tr\/wp-json\/wp\/v2\/comments?post=23497"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/purematrixchem.com\/tr\/wp-json\/wp\/v2\/media\/29431"}],"wp:attachment":[{"href":"https:\/\/purematrixchem.com\/tr\/wp-json\/wp\/v2\/media?parent=23497"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/purematrixchem.com\/tr\/wp-json\/wp\/v2\/product_brand?post=23497"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/purematrixchem.com\/tr\/wp-json\/wp\/v2\/product_cat?post=23497"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/purematrixchem.com\/tr\/wp-json\/wp\/v2\/product_tag?post=23497"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}