{"id":23378,"date":"2025-04-13T17:39:38","date_gmt":"2025-04-13T17:39:38","guid":{"rendered":"https:\/\/purematrixchem.com\/?post_type=product&p=23378"},"modified":"2026-06-28T11:55:29","modified_gmt":"2026-06-28T10:55:29","slug":"eskalin-hidroklorur","status":"publish","type":"product","link":"https:\/\/purematrixchem.com\/tr\/magaza\/neredeyse-yasaklandi\/eskalin-hidroklorur\/","title":{"rendered":"Escaline hidroklor\u00fcr"},"content":{"rendered":"

Escaline Hydrochloride - Wetenschappelijke Productdocumentatie<\/strong><\/h3>\n

\ud83d\udd2c Kimyasal \u00d6zellikler<\/strong><\/h4>\n

Escaline (4-ethoxy-3,5-dimethoxyfenethylamine) hydrochloride, yap\u0131sal olarak meskaline benzeyen yar\u0131 sentetik bir fenetilaminederivaatt\u0131r. Bu madde, ilgin\u00e7 farmakolojik profili nedeniyle en iyi \u015fekilde kullan\u0131lm\u0131\u015ft\u0131r.<\/p>\n

Kernparameters:<\/em><\/p>\n

    \n
  • \n

    IUPAC-naam<\/strong>: 2-(4-etoksi-3,5-dimetoksifenil)etan-1-amin hidroklor\u00fcr<\/p>\n<\/li>\n

  • \n

    Molek\u00fclform\u00fcl<\/strong>: C\u2081\u2082H\u2081\u2089NO\u2083 - HCl<\/p>\n<\/li>\n

  • \n

    Molecuulgewicht<\/strong>: 261,75 g\/mol<\/p>\n<\/li>\n

  • \n

    Zuiverheid<\/strong>: \u226598% (HPLC-UV bij 280 nm)<\/p>\n<\/li>\n

  • \n

    Vorm<\/strong>: Wit kristallijn poeder<\/p>\n<\/li>\n

  • \n

    Smeltpunt<\/strong>: 243-245\u00b0C (ontleedt)<\/p>\n<\/li>\n

  • \n

    Oplosbaarheid<\/strong>: 50 mg\/ml su i\u00e7inde, 30 mg\/ml metanol i\u00e7inde<\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddea Wetenschappelijke Toepassingen<\/strong><\/h4>\n
      \n
    1. \n

      N\u00f6rofarmakolojik ara\u015ft\u0131rma<\/strong>:<\/p>\n

        \n
      • \n

        5-HT\u2082A resept\u00f6r ba\u011flanma \u00e7al\u0131\u015fmalar\u0131 (Ki = 120 nM)<\/p>\n<\/li>\n

      • \n

        Meskalin ve di\u011fer fenetilaminler ile ilgili \u00e7al\u0131\u015fmalar<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

      • \n

        Gedragsonderzoek<\/strong>:<\/p>\n

          \n
        • \n

          Gece kontroll\u00fc ortamlarda diyergedrag \u00fczerindeki etkiler<\/p>\n<\/li>\n

        • \n

          Zoogdier-modellere g\u00f6re doz-yan\u0131t ili\u015fkileri<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

        • \n

          Metabolizma \u00e7al\u0131\u015fmalar\u0131<\/strong>:<\/p>\n

            \n
          • \n

            O-dealkylatie kinetiek onderzoek<\/p>\n<\/li>\n

          • \n

            CYP2D6 etkile\u015fimieprofiel<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2696\ufe0f Aanbevolen Doseringen voor Onderzoek<\/strong><\/h4>\n

            Deneysel haklar:<\/em><\/p>\n

            \n\n\n\n\n\n\n\n
            Model<\/th>\nDozajlama<\/th>\nAdministratieweg<\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/td>\n10-100 \u03bcM<\/td>\nCelcultuurmedium<\/td>\n<\/tr>\n
            Kleine dieren<\/td>\n1-5 mg\/kg<\/td>\n\u0130ntraperitoneal<\/td>\n<\/tr>\n
            Primaten<\/td>\n0,2-1 mg\/kg<\/td>\nOraal<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *B\u0131rak\u0131n: Dozaj etkisi 3 mg\/kg'a kadar*<\/p>\n

            \u26a0\ufe0f Veiligheidsaspecten & Risico's<\/strong><\/h4>\n
              \n
            1. \n

              Toksikolojik veriler<\/strong>:<\/p>\n

                \n
              • \n

                LD\u2085\u2080 (muis, i.v.): 185 mg\/kg<\/p>\n<\/li>\n

              • \n

                NOAEL: 0,75 mg\/kg\/g\u00fcn (28 g\u00fcnl\u00fck \u00e7al\u0131\u015fma)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

              • \n

                Bijwerkingenprofiel<\/strong>:<\/p>\n

                  \n
                • \n

                  <2 mg\/kg: Minimal fizyolojik etkiler<\/p>\n<\/li>\n

                • \n

                  2-6 mg\/kg: Sensorische modulatie<\/p>\n<\/li>\n

                • \n
                  \n

                  6 mg\/kg: Potansiyel hemodinamik etkiler<\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n

                • \n

                  Kritische interacties<\/strong>:<\/p>\n

                    \n
                  • \n

                    Gevaarlijk<\/strong>: MAO-remmers, serotonergische middelen<\/p>\n<\/li>\n

                  • \n

                    Risicovol<\/strong>: Vazokonstrikt\u00f6rler, antipsikotikler<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                    \ud83d\udcca Kwaliteitscontrole & Analytische Data<\/strong><\/h4>\n
                      \n
                    • \n

                      HPLC-puurheid<\/strong>: 98,2% (C18-kolom, 60:40 H\u2082O:MeCN)<\/p>\n<\/li>\n

                    • \n

                      Resterende oplosmiddelen<\/strong>: <0,1% (GC-MS)<\/p>\n<\/li>\n

                    • \n

                      Stabilite verileri<\/strong>:<\/p>\n

                        \n
                      • \n

                        \u00c7al\u0131\u015fma s\u0131cakl\u0131\u011f\u0131: -20\u00b0C'de 24 ay<\/p>\n<\/li>\n

                      • \n

                        Kamertemperatuur: 6 ay (argonun yan\u0131nda)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                        \u2753 Veelgestelde Onderzoeksvragen<\/strong><\/h4>\n

                        S1: \u00c7al\u0131\u015fma mekanizmas\u0131 nedir?<\/strong>
                        \nA: 5-HT\u2082A resept\u00f6ragonisti olarak primer \u00e7al\u0131\u015fma ve dopaminerge sistemlerinde sekonder etki.<\/p>\n

                        S2: Meskalinin g\u00fcc\u00fc nereden geliyor?<\/strong>
                        \nC: 1,5 kat daha y\u00fcksek al\u0131c\u0131 kapasitesi ancak daha uzun \u00e7al\u0131\u015fma s\u00fcresi (8-10 uur).<\/p>\n

                        S3: Optimum opslagcondities nedir?<\/strong>
                        \nA: -20\u00b0C'de inert gaz ile amber renkli \u015fi\u015felerde.<\/p>\n

                        S4: Genotoksik riskler var m\u0131?<\/strong>
                        \nA: Ames-testi <1 mM i\u00e7in negatif, ancak kromozom test verileri iyi.<\/p>\n

                        \ud83d\udccc Onderzoeksbeperkingen<\/strong><\/h4>\n
                          \n
                        • \n

                          Kronik \u015fi\u015fme \u00fczerine daha fazla veri<\/p>\n<\/li>\n

                        • \n

                          N\u00f6roplastisitenin Beklenen Etkileri<\/p>\n<\/li>\n

                        • \n

                          T\u00fcrler aras\u0131 de\u011fi\u015fken metabolizma<\/p>\n<\/li>\n<\/ul>\n

                          \ud83d\udd0d Wetenschappers i\u00e7in Sonu\u00e7lar<\/strong><\/h4>\n

                          Escaline hidroklor\u00fcr, stabilite ve \u00e7al\u0131\u015fma dayan\u0131kl\u0131l\u0131\u011f\u0131n\u0131n e\u015fsiz bir kombinasyonunu sa\u011flayarak vergisel serotoninerjik deneyler i\u00e7in son derece geli\u015fmi\u015f mogelijkhedenler sa\u011flar. Hidroklor\u00fcr formu, laboratuvar testleri i\u00e7in uygun bir kolayl\u0131k sa\u011flar.<\/p>\n

                          Yasal Uyar\u0131: Bu \u00fcr\u00fcn, akredite laboratuvarlarda \u0131slak uygulama \u00e7al\u0131\u015fmalar\u0131 i\u00e7in uygundur. Tan\u0131 ama\u00e7l\u0131 insan kullan\u0131m\u0131 i\u00e7in uygun de\u011fildir. T\u00fcm deneyler yerel kurallara ve etik kurallara uygun olarak yap\u0131lmal\u0131d\u0131r.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

                          Escaline hydrochloride eigenschappen<\/span><\/h3>\n

                          Synoniem:<\/strong> 3,5-dimetoksi-4-etoksifenetilamin hidroklor\u00fcr
                          \nCAS Nummer:<\/strong> 39201-82-6
                          \nForm\u00fcl:<\/strong> 2-{3,5-dimetoksi-4-etiloksifenil}etan-1-amin hidroklor\u00fcr
                          \nMolmassa:<\/strong> 261,8 g\/mol
                          \nZuiverheid:<\/strong> >97%<\/p>","protected":false},"featured_media":29416,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[82],"product_cat":[322,535,80],"product_tag":[1213],"class_list":{"0":"post-23378","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_brand-research-chemical","7":"product_cat-bijna-verboden","8":"product_cat-escaline","9":"product_cat-fenethylamine","10":"product_tag-escaline-hydrochloride-nl","12":"first","13":"instock","14":"taxable","15":"shipping-taxable","16":"purchasable","17":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/purematrixchem.com\/tr\/wp-json\/wp\/v2\/product\/23378","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/purematrixchem.com\/tr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/purematrixchem.com\/tr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/purematrixchem.com\/tr\/wp-json\/wp\/v2\/comments?post=23378"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/purematrixchem.com\/tr\/wp-json\/wp\/v2\/media\/29416"}],"wp:attachment":[{"href":"https:\/\/purematrixchem.com\/tr\/wp-json\/wp\/v2\/media?parent=23378"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/purematrixchem.com\/tr\/wp-json\/wp\/v2\/product_brand?post=23378"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/purematrixchem.com\/tr\/wp-json\/wp\/v2\/product_cat?post=23378"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/purematrixchem.com\/tr\/wp-json\/wp\/v2\/product_tag?post=23378"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}