5-MeO-DMT freebase

5-MeO-DMT Freebase – Scientific Product Documentation

General Description

5-MeO-DMT (5-Methoxy-N,N-dimethyltryptamine) freebase is a naturally occurring tryptamine with a potent psychoactive profile, found in various plants and animal secretions. In its freebase form, it offers superior volatility for certain research methods, making it valuable for pharmacological and neuroscience studies.

---

Technical Specifications

---

Scientific Applications

1. Neuropharmacological Research

• Serotonergic Action:  Potent 5-HT₁ₐ/₂ₐ agonist, relevant for studies of consciousness modulation.

• EEG/fMRI studies:  Investigation of acute effects on brain wave patterns (e.g. gamma oscillations).

• Neuroplasticity:  Possible BDNF-enhancing effects (in animal models).

2. Metabolic & Toxicological Studies

• MAO-dependent metabolism:  Investigation of CYP2D6 and MAO-A degradation pathways.

• Dose-dependent toxicity:  Determination of safety margins in cell cultures.

3. Comparative Pharmacology

• Compared to DMT:  Higher potency but shorter duration of action (15-30 min when inhaled).

• Compared to psilocybin:  Differences in receptor affinity and subjective effects.

---

Experimental Guidelines

Recommended Concentrations (In Vitro)

Safety protocols

• Personal Protection:  Lab coat, nitrile gloves, safety glasses, FFP2 mask when handling powder.

• Ventilation:  Always work under a fume cupboard when heating/evaporating.

• Хранение:  In amber vials, under argon, at -20°C (long term).

---

Stability & Storage

• Срок годности:

  • Room temperature: <24 hours in solution.

  • 4°C: Stable for 3 days (under argon).

  • -20°C: >6 months (unchanged purity).

• Degradation products:

  • Oxidation to indole derivatives (check by TLC/HPLC).

---

Analytical Certification

Each batch includes:

1. HPLC-UV chromatogram  (λ=280 nm, C18 column)

2. GC-MS confirmation  (characteristic fragments: m/z 174, 160)

3. Анализ остаточного растворителя  (≤500 ppm)

4. Water content  (Karl Fischer, <1%)

---

Legal Status (Netherlands)

• Opium Act:  Not explicitly regulated, but possibly under analogous legislation.

• Legislation:  A licence is required for scientific institutions (Appendix 2, Opium Act).

• Export restrictions:  CITES listing (due to natural sources such as  Incilius alvarius ).

---

Frequently Asked Questions (FAQ)

Q1: What is the difference between freebase and fumaric acid salt?
A: Freebase is more volatile (suitable for evaporation experiments), while fumaric acid salt is more stable in solutions.

Q2: How is 5-MeO-DFT detected in toxicology screens?
A: Identifiable by:

• LC-MS/MS (precursor ion m/z 219 → product ion m/z 174)

• Immunoassays: Cross-reactivity with some DMT tests (≤30%).

Q3: Are there any known pharmacokinetic interactions?
A:  Опасные комбинации:

• MAO inhibitors (risk of serotonin syndrome).

• SSRIs (reduced efficacy due to competition).

Q4: How to dispose of waste?
A: Inactivate with:

1. Dilute hydrochloric acid (0.1M) for neutralization.

2. Absorption with activated carbon.

3. Dispose of as  hazardous chemical waste  (UN number: 3249).

---

References & Contact

Key publications:

• Szára, S. (2007). “DMT and 5-MeO-DMT: Early human studies”.

• Uthaug et al. (2021). “Psychopharmacology of 5-MeO-DMT”.

---

This product is intended solely for legitimate scientific research. Not for human or veterinary use. Users must comply with all local regulations.