5-MeO-DMT hydrochloride

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5-MeO-DMT hydrochloride properties

Синоним: 5-methoxy-N,N-dimethyltryptamine hydrochloride
Номер CAS: n/a
Формула: 3-[2-(dimethylamino)ethyl]-5-methoxyindole hydrochloride
Молярная масса: 254.8 g/mol
Чистота: >97%

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5-MeO-DMT Hydrochloride – Scientific Product Documentation

General Description

5-MeO-DMT hydrochloride (5-Methoxy-N,N-dimethyltryptamine HCl) is a water-soluble salt of classical tryptamine, particularly suitable for pharmacological research due to its increased stability and bioavailability compared to the freebase form.

Technical Specifications

Parameter	Specification
Chemical Formula	C₁₃H₁₈N₂O · HCl
Molecular Weight	254.75 g/mol
Purity	≥98% (analyzed by HPLC-UV)
Appearance	White to light yellow crystalline powder
Растворимость	High in water (>50 mg/ml), methanol, PBS
Melting point	243-247°C (decomposes)
Стабильность	Hygroscopic; store in dry conditions

Scientific Applications

1. Neuropharmacology & Behavioral Research

Serotonin receptor studies: Potent 5-HT₁ₐ/₂ₐ agonist with rapid cerebral penetration.
Animal experiments (in vivo): Behavioural paradigms (e.g. head-twitch response in rodents).
Electrophysiology: Effects on neuronal oscillations (e.g., gamma-band activity).

2. Biochemical & Molecular Studies

Intracellular signaling: cAMP accumulation and β-arrestin recruitment assays.
Enzyme kinetics: MAO-A metabolism (IC₅₀ ~2-5 μM).

3. Clinically Relevant Research

Dose-response relationships: Preclinical safety profiling.
Comparative pharmacology: Towards psilocybin, DMT, and other tryptamines.

Experimental Guidelines

Recommended Concentrations

Application	Concentration range	Solvent
Cell cultures (in vitro)	1 nM – 10 μM	PBS/DMEM (≤0.1% DMSO)
Receptor assays	0.1 – 100 μM	Tris-HCl buffer (pH 7.4)
Animal studies (ip/iv)	0.1 – 5 mg/kg	Sterile saline solution

Меры безопасности

Личная защита: Lab coat, gloves (nitrile), safety glasses.
Handling: Hygroscopic – close promptly after use.
Хранение: Airtight, under argon, at -20°C (prevent hydrolysis).

Stability & Storage

Срок годности:
- -20°C: >2 years (unchanged purity).
- 4°C: 6 months (in dry environment).
Relegation:
- Hydrolysis on prolonged exposure to moisture (monitor by HPLC).

Analytical Validation

Each batch comes with:

HPLC-UV chromatogram (C18 column, retention time ~6.2 min).
MS/MS fragmentation (characteristic ions: m/z 219 → 174, 160).
Residual solvents (meet ICH Q3C guidelines).

Legal Status (Netherlands/EU)

Narcotics legislation: Not explicitly mentioned in the Opium Act, but possibly under analogous legislation (Appendix II).
Scientific use: Permit required for institutions (CCMO approval for animal testing).
Export control: Subject to EU Regulation 2019/1998 (psychotropic substances).

Frequently Asked Questions (FAQ)

Q1 : What are the advantages of HCl over freebase?

Improved solubility (ideal for injection studies).
Longer shelf stability at room temperature.

Q2: Is 5-MeO-DMT-HCl detectable in drug tests?
A: Yes, via:

LC-MS/MS (recognized as 5-MeO-DMT + HCl adduct).
Immunoassays: Cross-reactivity with DMT (~15-20%).

Q3: Are there risks when combining with MAO inhibitors?
A: Absolutely.

Increased risk of serotonin syndrome (avoid combination!).
Use only in MAO-free models.

Q4: How to dispose of waste?
A:

Neutralize with sodium bicarbonate (pH 7-8).
Adsorb with activated carbon .
Dispose of as hazardous chemical waste (UN 3249, Class 6.1).

References & Contact

Core literature:

Shen et al. (2010). “Pharmacology of 5-MeO-DMT derivatives”. J Psychopharmacol .
Kaasik et al. (2021). “Metabolic pathways of 5-MeO-DMT”. Xenobiotics .

This product is intended only for authorized scientific research. Not for human consumption or diagnostic use. Please observe local regulations.

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