{"id":23531,"date":"2025-04-13T17:39:56","date_gmt":"2025-04-13T17:39:56","guid":{"rendered":"https:\/\/purematrixchem.com\/?post_type=product&p=23531"},"modified":"2026-01-13T13:29:44","modified_gmt":"2026-01-13T12:29:44","slug":"ept-fumarato-n-etil-n-propil-triptamina","status":"publish","type":"product","link":"https:\/\/purematrixchem.com\/pt\/comprar\/ept\/ept-fumarato-n-etil-n-propil-triptamina\/","title":{"rendered":"Fumarato de EPT (N-etil-N-propiltriptamina)"},"content":{"rendered":"

Fumarato de EPT (N-etil-N-propiltriptamina) - Descri\u00e7\u00e3o cient\u00edfica do produto<\/span><\/span><\/strong><\/h3>\n

Carater\u00edsticas gerais<\/span><\/span><\/strong><\/h4>\n

O fumarato de EPT \u00e9 um produto qu\u00edmico de investiga\u00e7\u00e3o da classe das triptaminas, caracterizado pelo seu padr\u00e3o \u00fanico de substitui\u00e7\u00e3o N-etil-N-propil. Este composto apresenta semelhan\u00e7as estruturais com as triptaminas conhecidas, como a DMT e a MET, mas distingue-se por propriedades farmacodin\u00e2micas espec\u00edficas.<\/span><\/span><\/p>\n

Especifica\u00e7\u00f5es principais:<\/span><\/span><\/strong><\/p>\n

    \n
  • \n

    Pureza qu\u00edmica:<\/span><\/span><\/strong> \u00a0>98% (verificado por HPLC-MS)<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Estabilidade molecular:<\/span><\/span><\/strong> \u00a0Excelente estabilidade devido \u00e0 forma\u00e7\u00e3o de sais de fumarato<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Solubilidade:<\/span><\/span><\/strong> \u00a0Muito sol\u00favel em \u00e1gua e em solventes org\u00e2nicos<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Condi\u00e7\u00f5es de armazenamento:<\/span><\/span><\/strong> \u00a0Estabilidade a longo prazo a -20\u00b0C em atmosfera de g\u00e1s inerte<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    Aplica\u00e7\u00f5es cient\u00edficas<\/span><\/span><\/strong><\/h4>\n
      \n
    1. \n

      Investiga\u00e7\u00e3o Neurofarmacol\u00f3gica:<\/span><\/span><\/strong><\/p>\n

        \n
      • \n

        Intera\u00e7\u00f5es com receptores serotonin\u00e9rgicos (5-HT1A\/2A\/2C)<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Estudos de inibi\u00e7\u00e3o da monoamina oxidase<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Mecanismos de liberta\u00e7\u00e3o de neurotransmissores<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

      • \n

        Estudos metab\u00f3licos:<\/span><\/span><\/strong><\/p>\n

          \n
        • \n

          Perfil do metabolismo dos microssomas hep\u00e1ticos<\/span><\/span><\/p>\n<\/li>\n

        • \n

          An\u00e1lise da intera\u00e7\u00e3o do citocromo P450<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

        • \n

          Farmacologia comparada:<\/span><\/span><\/strong><\/p>\n

            \n
          • \n

            Rela\u00e7\u00f5es estrutura-atividade versus outras N,N-dialquiltriptaminas<\/span><\/span><\/p>\n<\/li>\n

          • \n

            Caracteriza\u00e7\u00e3o da dose-resposta in vitro<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            Diretrizes experimentais<\/span><\/span><\/strong><\/h4>\n

            Intervalos de dosagem para estudos in vitro:<\/span><\/span><\/strong><\/p>\n

            \n\n\n\n\n\n\n\n
            Aplica\u00e7\u00e3o<\/span><\/span><\/th>\nIntervalo de concentra\u00e7\u00e3o<\/span><\/span><\/th>\nPer\u00edodo de incuba\u00e7\u00e3o ideal<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n
            Liga\u00e7\u00e3o dos receptores<\/span><\/span><\/td>\n10 nM - 1 \u03bcM<\/span><\/span><\/td>\n30-60 minutos<\/span><\/span><\/td>\n<\/tr>\n
            Estudos de metabolismo<\/span><\/span><\/td>\n1-100 \u03bcM<\/span><\/span><\/td>\n2-4 horas<\/span><\/span><\/td>\n<\/tr>\n
            Toxicidade celular<\/span><\/span><\/td>\n10-500 \u03bcM<\/span><\/span><\/td>\n24-48 horas<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            Protocolos de seguran\u00e7a:<\/span><\/span><\/strong><\/p>\n

              \n
            • \n

              Trabalhar sempre em condi\u00e7\u00f5es laboratoriais controladas<\/span><\/span><\/p>\n<\/li>\n

            • \n

              \u00c9 necess\u00e1rio equipamento de prote\u00e7\u00e3o individual (bata de laborat\u00f3rio, luvas de nitrilo, \u00f3culos de seguran\u00e7a)<\/span><\/span><\/p>\n<\/li>\n

            • \n

              Utilizar apenas num exaustor quando manusear solventes<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

              Dados de estabilidade<\/span><\/span><\/strong><\/h4>\n

              Estabilidade documentada:<\/span><\/span><\/strong><\/p>\n

                \n
              • \n

                Temperatura ambiente: <72 horas em solu\u00e7\u00e3o<\/span><\/span><\/p>\n<\/li>\n

              • \n

                Refrigerado (4\u00b0C): est\u00e1vel durante 1 semana<\/span><\/span><\/p>\n<\/li>\n

              • \n

                Congelado (-20\u00b0C): est\u00e1vel durante >6 meses<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                Armazenamento recomendado:<\/span><\/span><\/strong><\/p>\n

                  \n
                • \n

                  Embalagem prim\u00e1ria: Frascos de vidro \u00e2mbar com fecho de PTFE<\/span><\/span><\/p>\n<\/li>\n

                • \n

                  Embalagem secund\u00e1ria: Selado a v\u00e1cuo com embalagem de s\u00edlica gel<\/span><\/span><\/p>\n<\/li>\n

                • \n

                  Condi\u00e7\u00f5es de armazenamento: -20\u00b0C sob atmosfera de \u00e1rgon<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                  Certifica\u00e7\u00e3o anal\u00edtica<\/span><\/span><\/strong><\/h4>\n

                  Cada lote \u00e9 fornecido com:<\/span><\/span><\/p>\n

                    \n
                  1. \n

                    An\u00e1lise exaustiva por HPLC (dete\u00e7\u00e3o UV\/VIS)<\/span><\/span><\/p>\n<\/li>\n

                  2. \n

                    Confirma\u00e7\u00e3o por espetrometria de massa (LC-MS\/MS)<\/span><\/span><\/p>\n<\/li>\n

                  3. \n

                    An\u00e1lise de solventes residuais<\/span><\/span><\/p>\n<\/li>\n

                  4. \n

                    Determina\u00e7\u00e3o do teor de \u00e1gua (Karl Fischer)<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                    Estatuto jur\u00eddico e \u00e9tica<\/span><\/span><\/strong><\/h4>\n

                    Regulamentos neerlandeses:<\/span><\/span><\/strong><\/p>\n

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                    • \n

                      Atualmente n\u00e3o inclu\u00eddo na Lei do \u00d3pio<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      V\u00e1lido ao abrigo da legisla\u00e7\u00e3o geral sobre medicamentos para produtos qu\u00edmicos de investiga\u00e7\u00e3o<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Registo obrigat\u00f3rio das institui\u00e7\u00f5es cient\u00edficas<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      Diretrizes \u00e9ticas:<\/span><\/span><\/strong><\/p>\n

                        \n
                      • \n

                        Apenas para utiliza\u00e7\u00e3o em investiga\u00e7\u00e3o n\u00e3o cl\u00ednica<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        Proibido para administra\u00e7\u00e3o humana ou animal<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        An\u00e1lise \u00e9tica obrigat\u00f3ria da investiga\u00e7\u00e3o acad\u00e9mica<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                        Perguntas frequentes<\/span><\/span><\/strong><\/h4>\n

                        Q1: Como \u00e9 que o EPT se compara \u00e0s triptaminas estruturalmente semelhantes?<\/span><\/span><\/strong>
                        \n R: A substitui\u00e7\u00e3o etil-propil apresenta propriedades farmacocin\u00e9ticas \u00fanicas, particularmente em:<\/span><\/span><\/p>\n

                          \n
                        • \n

                          Perfil de lipofilicidade (valor logP: 2,1)<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Capacidade de liga\u00e7\u00e3o \u00e0s prote\u00ednas (88-92%)<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Penetra\u00e7\u00e3o na barreira cerebral (r\u00e1cio de 0,65 em rela\u00e7\u00e3o \u00e0 DMT)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          P2: Quais s\u00e3o as op\u00e7\u00f5es de dete\u00e7\u00e3o nos rastreios normais de drogas?<\/span><\/span><\/strong>
                          \n R: A EPT n\u00e3o \u00e9 reconhecida por imunoensaios convencionais, mas \u00e9 detet\u00e1vel atrav\u00e9s de:<\/span><\/span><\/p>\n

                            \n
                          • \n

                            GC-MS (fragmenta\u00e7\u00e3o carater\u00edstica a m\/z 130, 144)<\/span><\/span><\/p>\n<\/li>\n

                          • \n

                            LC-QTOF (medi\u00e7\u00e3o exacta da massa molecular)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                            Q3: Existem intera\u00e7\u00f5es conhecidas com medicamentos?<\/span><\/span><\/strong>
                            \n R: As intera\u00e7\u00f5es te\u00f3ricas s\u00e3o poss\u00edveis com:<\/span><\/span><\/p>\n

                              \n
                            • \n

                              Inibidores da MAO (efeito de potencia\u00e7\u00e3o)<\/span><\/span><\/p>\n<\/li>\n

                            • \n

                              SSRIs (inibi\u00e7\u00e3o competitiva)<\/span><\/span><\/p>\n<\/li>\n

                            • \n

                              Antipsic\u00f3ticos (competi\u00e7\u00e3o de receptores)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                              Q4: Qual \u00e9 a elimina\u00e7\u00e3o de res\u00edduos recomendada?<\/span><\/span><\/strong>
                              \n R: Seguir o protocolo relativo aos res\u00edduos perigosos:<\/span><\/span><\/p>\n

                                \n
                              • \n

                                Neutralizar com \u00e1cido clor\u00eddrico dilu\u00eddo (0,1M)<\/span><\/span><\/p>\n<\/li>\n

                              • \n

                                Absorver com material adequado (por exemplo, vermiculite)<\/span><\/span><\/p>\n<\/li>\n

                              • \n

                                Eliminar como res\u00edduo qu\u00edmico perigoso (n\u00famero CE: 404-860-3)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                                Refer\u00eancias cient\u00edficas<\/span><\/span><\/strong><\/h4>\n

                                Refer\u00eancias bibliogr\u00e1ficas importantes:<\/span><\/span><\/p>\n

                                  \n
                                1. \n

                                  Nichols, D. E. (2018). \u201cRela\u00e7\u00f5es estrutura-atividade das triptaminas\u201d<\/span><\/span><\/p>\n<\/li>\n

                                2. \n

                                  Brandt et al. (2020). \u201cCaracteriza\u00e7\u00e3o anal\u00edtica de novas subst\u00e2ncias psicoactivas\u201d<\/span><\/span><\/p>\n<\/li>\n

                                3. \n

                                  Sistema de Alerta R\u00e1pido da UE (2023). \u201cAvalia\u00e7\u00e3o dos riscos de novos derivados de triptamina\u201d<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                                  Este produto destina-se exclusivamente \u00e0 investiga\u00e7\u00e3o cient\u00edfica autorizada por pessoal qualificado. Todas as informa\u00e7\u00f5es s\u00e3o fornecidas sem qualquer garantia impl\u00edcita. Os utilizadores s\u00e3o respons\u00e1veis pelo cumprimento dos regulamentos locais.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                                  EPT fumarate properties<\/span><\/span><\/span><\/span><\/span><\/h3>\n

                                  Synonym:<\/span><\/span><\/span><\/span><\/strong> N-ethyl-N-propyltryptamine fumarate <\/span><\/span><\/span><\/span>
                                  \nCAS Number:<\/span><\/span><\/span><\/span><\/strong> n\/a <\/span><\/span><\/span><\/span>
                                  \nFormula:<\/span><\/span><\/span><\/span><\/strong> 3-[2-(ethyl(propyl)amino)ethyl]-1H-indole fumarate <\/span><\/span><\/span><\/span>
                                  \nMolar Mass:<\/span><\/span><\/span><\/span><\/strong> 346.4 g\/mol <\/span><\/span><\/span><\/span>
                                  \nPurity:<\/span><\/span><\/span><\/span><\/strong> >97%<\/span><\/span><\/span><\/span><\/p>\n","protected":false},"featured_media":29418,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[82],"product_cat":[509,381],"product_tag":[326],"class_list":{"0":"post-23531","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_brand-research-chemical","7":"product_cat-ept","8":"product_cat-tryptamines","9":"product_tag-nl","11":"first","12":"instock","13":"taxable","14":"shipping-taxable","15":"purchasable","16":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/purematrixchem.com\/pt\/wp-json\/wp\/v2\/product\/23531","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/purematrixchem.com\/pt\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/purematrixchem.com\/pt\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/purematrixchem.com\/pt\/wp-json\/wp\/v2\/comments?post=23531"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/purematrixchem.com\/pt\/wp-json\/wp\/v2\/media\/29418"}],"wp:attachment":[{"href":"https:\/\/purematrixchem.com\/pt\/wp-json\/wp\/v2\/media?parent=23531"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/purematrixchem.com\/pt\/wp-json\/wp\/v2\/product_brand?post=23531"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/purematrixchem.com\/pt\/wp-json\/wp\/v2\/product_cat?post=23531"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/purematrixchem.com\/pt\/wp-json\/wp\/v2\/product_tag?post=23531"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}