{"id":24756,"date":"2025-04-13T17:42:59","date_gmt":"2025-04-13T17:42:59","guid":{"rendered":"https:\/\/purematrixchem.com\/?post_type=product&#038;p=24756"},"modified":"2025-12-19T08:51:07","modified_gmt":"2025-12-19T07:51:07","slug":"pastillas-de-bromazolam","status":"publish","type":"product","link":"https:\/\/purematrixchem.com\/es\/comercio\/benzodiazepinas\/pastillas-de-bromazolam\/","title":{"rendered":"Bromazolam 3 MG Pellets"},"content":{"rendered":"<h3><strong>Richtlijn Onderzoeksmethodologische: An\u00e1lisis y evaluaci\u00f3n farmacol\u00f3gica de los gr\u00e1nulos de bromazolam<\/strong><\/h3>\n<p class=\"ds-markdown-paragraph\"><strong>1. T\u00edtulo del informe<\/strong><br \/>\nUn t\u00edtulo doble y espec\u00edfico:<br \/>\n\u201cOntwikkeling and validation of a gevoelige LC-MS\/MS method for the detection and kwantificering of bromazolam in forensisch relevant matrices\u201d.\u201d<br \/>\n<em>de<\/em><br \/>\n\u201cFarmacokinetische karakterisering en metabolietenprofiel van de nieuwe psychoactieve stof bromazolam in een\u00a0<em>in vitro<\/em>\u00a0modelo\u201d.\u201d<\/p>\n<p class=\"ds-markdown-paragraph\"><strong>2. Introducci\u00f3n y resoluci\u00f3n de problemas<\/strong><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Achtergrond:<\/strong>\u00a0Presenta el bromazolam como una triazolo-1,4-benzodiazepina, una \u2018benzodiazepina de dise\u00f1o\u2019 (DBZD) o una \u2018nueva sustancia psicoactiva\u2019 (NPS). Describe la relaci\u00f3n estructural con el alprazolam, su efecto farmacol\u00f3gico (ansiol\u00edtico, sedante, relajante) y su uso en medicina.<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Resoluci\u00f3n de problemas:<\/strong>\u00a0Identificar la urgencia. El f\u00e1rmaco se encuentra en el mercado ilegal de las drogas, est\u00e1 muy extendido, y existe un problema con los m\u00e9todos de detecci\u00f3n para la toxicolog\u00eda cl\u00ednica y forense. El riesgo de sobredosificaci\u00f3n, abuso e interacciones es elevado.<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Onderzoeksvraag:<\/strong>\u00a0Formuleer de centrale vraag, bijv.: \u201cWat is de analytische gevoeligheid en specificiteit van een nieuwe ontwikkelde LC-MS\/MS method voor de bepaling van bromazolam en zijn belangrijkste metabolieten in bloedplasma?\u201d<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Doelstellingen:<\/strong><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Hoofddoel:<\/strong>\u00a0El uso de un m\u00e9todo de an\u00e1lisis robusto y fiable para la identificaci\u00f3n y cuantificaci\u00f3n del bromazolam.<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Medidas espec\u00edficas:<\/strong><\/p>\n<ol start=\"1\">\n<li>\n<p class=\"ds-markdown-paragraph\">Optimaliseren van monstervoorbehandeling (bv. vloeistof-vloeistofextractie of vaste-fase-extractie) voor verschillende matrices (bloed, urine, poedermonsters).<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\">Valideren van een LC-MS\/MS methode volgens gevestigde richtlijnen (SWGTOX\/EMA).<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\">Identificeren van belangrijke humane\u00a0<em>in vitro<\/em>\u00a0metabolieten met behulp van hoog-resolutie massaspectrometrie (HRMS).<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\">An\u00e1lisis de los par\u00e1metros farmacocin\u00e9ticos (por ejemplo, la media ponderaci\u00f3n y el nivel de alcoholemia) en un estudio pertinente\u00a0<em>in vitro<\/em>\u00a0sistema (bv. microsomale incubaties).<\/p>\n<\/li>\n<\/ol>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p class=\"ds-markdown-paragraph\"><strong>3. Literatuuronderzoek<\/strong><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\">Inventariseer de beschikbare (weinige) wetenschappelijke publiaties en forensische casusrapporten over bromazolam.<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\">Conozca la estructura qu\u00edmica, los efectos secundarios y las principales reacciones sint\u00e9ticas.<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\">Revisi\u00f3n de los mejores m\u00e9todos de an\u00e1lisis de las benzodiacepinas y otras NSP.<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\">Recopilaci\u00f3n de datos de las redes de vigilancia, como el OEDT y el Nederlands Drugs Expertise Centrum (NDEC).<\/p>\n<\/li>\n<\/ul>\n<p class=\"ds-markdown-paragraph\"><strong>4. Onderzoeksmethodologie (Materiaal en Methoden)<\/strong><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>4.1 Tipo de b\u00fasqueda:<\/strong>\u00a0Investigaci\u00f3n experimental, anal\u00edtica y farmacol\u00f3gica b\u00e1sica.<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>4.2 Estudio sobre el trabajo:<\/strong>\u00a0M\u00e9todos de trabajo y\u00a0<em>in vitro<\/em>\u00a0experimenten.<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>4.3 Material:<\/strong><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Stoffen:<\/strong>\u00a0Cualquier est\u00e1ndar de referencia de bromazolam (si se vende en el comercio, o si se vende a trav\u00e9s de an\u00e1lisis forenses oficiales). Interne standaard isotopen-gelabelde (bv. een ander stabiel gelabeld benzodiazepine). Levermicrosomen menselijke of hepatocyten (voor\u00a0<em>in vitro<\/em>\u00a0estudios de metabolismo).<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Aparatos:<\/strong>\u00a0Sistema LC-MS\/MS (triple cuadrupolo), eventueel LC-HRMS (QTOF) for metabolietenscreening, vortex, centrifugadora, SPE-apparatuur.<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>4.4 Methoden:<\/strong><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Monstervoorbehandeling:<\/strong>\u00a0Indique el protocolo de extracci\u00f3n exacto para cada matriz. Para sangre: eiwitneerslag o SPE. Para poeders: oplossen y verdunnen.<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>An\u00e1lisis de instrumentos:<\/strong><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>LC-MS\/MS (voor kwantificering):<\/strong>\u00a0Optimizaci\u00f3n de la secuencia cromatogr\u00e1fica (columna C18) y de los par\u00e1metros MS\/MS (precursores y producci\u00f3n, energ\u00edas de colisi\u00f3n). Utilizar la Monitorizaci\u00f3n de Reacciones M\u00faltiples (MRM).<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Validaci\u00f3n:<\/strong>\u00a0Para una validaci\u00f3n completa de la linealidad, precisi\u00f3n (intradiaria e interdiaria), exactitud, extracci\u00f3n, efectos de matriz, LOD y LOQ.<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Detecci\u00f3n de metabolitos (LC-HRMS):<\/strong>\u00a0Incube el bromazolam con levermicrosomen. Exploraci\u00f3n de metabolitos similares mediante biotransformaciones (hidroxilaci\u00f3n, desmetilaci\u00f3n, glucuronideraci\u00f3n). Identificaci\u00f3n manual de masas exactas y fragmentos.<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><em>In vitro<\/em>\u00a0Farmacokinetiek:<\/strong>\u00a0La incubaci\u00f3n intr\u00ednseca y la semicongelaci\u00f3n en incubadoras micros\u00f3micas con alimentaci\u00f3n a baja temperatura y concentraci\u00f3n.<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p class=\"ds-markdown-paragraph\"><strong>5. An\u00e1lisis de datos y estad\u00edsticas<\/strong><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\">Utilice calibradores con correcci\u00f3n interna est\u00e1ndar para la calibraci\u00f3n.<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\">Analice los datos de validaci\u00f3n con los estad\u00edsticos descritos (medici\u00f3n, desviaci\u00f3n est\u00e1ndar, coeficiente de variaci\u00f3n (RSD%)).<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\">Para datos farmacocin\u00e9ticos: pasar modelos geschikte toe (bv. first-order decay) om parameters te schatten.<\/p>\n<\/li>\n<\/ul>\n<p class=\"ds-markdown-paragraph\"><strong>6. Ethische, Veiligheids- en Wettelijke Overwegingen<\/strong><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Veiligheid:<\/strong>\u00a0El bromazolam es un potente f\u00e1rmaco psicoactivo.\u00a0<strong>Vuelva a colocar todos los equipos en un entorno controlado:<\/strong>\u00a0zuurkast of safety cabinet, labjas, handschoenen (nitril), oogbescherming. Houd rekening met mogelijke besmetting van oppervlakken. Onttrek verdampte oplossingen via een afzuigsysteem.<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Wettelijk Kader:<\/strong>\u00a0El bromazolam es muy eficaz en los siguientes casos\u00a0<strong>Opiumwet<\/strong>\u00a0(Lijst II of mogelijk Lijst I, afhankelijk van juridische classificatie).\u00a0<strong>Noodzakelijk:<\/strong>\u00a0Zorg voor de vereiste\u00a0<strong>vergunningen<\/strong>\u00a0van de\u00a0<strong>Opiumwet<\/strong>\u00a0voor het wetenschappelijk bezit en gebruik van deze stof. Overleg hiervoor met de aangewezen functionaris (bv. de \u2018Ambtshalve Hoofd\u2019 of veiligheidsfunctionaris) binnen uw instelling.<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Ethiek:<\/strong>\u00a0Para la investigaci\u00f3n con materias primas o materiales humanos se requieren medidas METC adicionales. Zuivere analytische methododeontwikkeling valt hier meestal buiten, maar gebruik van (rest)humaan bloed of weefsel vereist wel ethische toetsing.<\/p>\n<\/li>\n<\/ul>\n<p class=\"ds-markdown-paragraph\"><strong>7. Tijdsplanning (diagrama de Gantt)<\/strong><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Fase 1 (M1-2):<\/strong>\u00a0Literatuurstudie &amp; verwerving\/aanvraag van referentiestandaarden en vergunningen.<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Fase 2 (M3-5):<\/strong>\u00a0Optimalisatie monstervoorbehandeling en LC-MS\/MS method.<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Fase 3 (M6-7):<\/strong>\u00a0Validaci\u00f3n completa del m\u00e9todo de an\u00e1lisis.<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Fase 4 (M8-9):<\/strong>\u00a0<em>In vitro<\/em>\u00a0metabolisme- en farmacokinetiekstudies.<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Fase 5 (M10-12):<\/strong>\u00a0An\u00e1lisis de datos, interpretaci\u00f3n y elaboraci\u00f3n de informes.<\/p>\n<\/li>\n<\/ul>\n<p class=\"ds-markdown-paragraph\"><strong>8. Verwachte Resultaten en Discussie (Kader)<\/strong><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\">Un m\u00e9todo seguro y fiable espec\u00edfico para el bromazolam.<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\">Conozca los metabolitos m\u00e1s importantes que puede detectar un forense en la orina.<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\">Eerste schattingen van pharmokinetische parameters, belangrijk voor het interpreteren van toxische concentraties.<\/p>\n<\/li>\n<\/ul>\n<p class=\"ds-markdown-paragraph\"><strong>9. Informaci\u00f3n sobre la investigaci\u00f3n<\/strong><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\">El bromazolam es un medicamento de venta con receta m\u00e9dica que se utiliza para tratar la disfunci\u00f3n er\u00e9ctil.<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><em>In vitro<\/em>\u00a0data zijn niet \u00e9\u00e9n-op-\u00e9\u00e9n vertaalbaar naar de\u00a0<em>in vivo<\/em>\u00a0situatie bij de mens.<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\">Se puede acceder a los \u201cviejos\u201d monstruos de la medicina forense.<\/p>\n<\/li>\n<\/ul>\n<p class=\"ds-markdown-paragraph\"><strong>10. Referentielijst<\/strong><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\">Gebruik gestandaardiseerde referentijl.<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\">Verwijs naar:<\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\">SWGTOX of EMA richtlijnen voor validatie.<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\">Publicaties over andere Designer Benzodiazepines (bv. etizolam, flualprazolam).<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\">Informes del OEDT y del Instituto Trimbos\/NDEC.<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\">De Nederlandse Opiumwet.<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<hr \/>\n<p class=\"ds-markdown-paragraph\"><strong>Essenti\u00eble Nederlandse Termen:<\/strong><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\">Bromazolam = Bromazolam<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\">Benzodiazepina de dise\u00f1o (DBZD) = Ontworpen Benzodiazepine \/ Designerbenzodiazepine<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\">Nieuwe Psychoactieve Stof (NPS) = Nuevo Sistema Psicoactivo (NPS)<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\">LC-MS\/MS = LC-MS\/MS<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\">Espectrometr\u00eda de masas de alta resoluci\u00f3n (HRMS) = Espectrometr\u00eda de masas de alta resoluci\u00f3n<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\">Validaci\u00f3n = Validaci\u00f3n<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\">Metaboliet = Metaboliet<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><em>In vitro<\/em>\u00a0=\u00a0<em>In vitro<\/em><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\">Farmacokinetiek = Farmacokinetiek<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\">Opiumwet = Opiumwet<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\">Vergunning = Vergunning<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\">Nederlands Drugs Expertise Centrum (NDEC) = Centro Holand\u00e9s de Especializaci\u00f3n Farmac\u00e9utica (NDEC)<\/p>\n<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<h3><span data-sheets-value=\"{\" data-sheets-userformat=\"{\">Bromazolam eigenschappen<\/span><\/h3>\n<p><span class=\"___SText_pr68d-red-team\" data-ui-name=\"Link.Text\">gr\u00e1nulos de bromazolam,\u00a0<\/span><\/p>\n<p><strong>Synoniem:<\/strong> Bromazolam<br \/>\n<strong>N\u00famero CAS:<\/strong> 71368-80-4<br \/>\n<strong>Molmassa:<\/strong> 353,223 g-mol<br \/>\n<strong>Zuiverheid:<\/strong> &gt;99%<\/p>\n<p>&nbsp;<\/p>","protected":false},"featured_media":29185,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[82],"product_cat":[76,384,443,324],"product_tag":[626,627,326],"class_list":{"0":"post-24756","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_brand-research-chemical","7":"product_cat-benzodiazepinen","8":"product_cat-bromazolam","9":"product_cat-bromazolam-pellets","10":"product_cat-pellets-for-pellet","11":"product_tag-bromazolam-pellets","12":"product_tag-bromazolam-pellets-3mg","13":"product_tag-nl","15":"first","16":"instock","17":"taxable","18":"shipping-taxable","19":"purchasable","20":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/purematrixchem.com\/es\/wp-json\/wp\/v2\/product\/24756","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/purematrixchem.com\/es\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/purematrixchem.com\/es\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/purematrixchem.com\/es\/wp-json\/wp\/v2\/comments?post=24756"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/purematrixchem.com\/es\/wp-json\/wp\/v2\/media\/29185"}],"wp:attachment":[{"href":"https:\/\/purematrixchem.com\/es\/wp-json\/wp\/v2\/media?parent=24756"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/purematrixchem.com\/es\/wp-json\/wp\/v2\/product_brand?post=24756"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/purematrixchem.com\/es\/wp-json\/wp\/v2\/product_cat?post=24756"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/purematrixchem.com\/es\/wp-json\/wp\/v2\/product_tag?post=24756"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}